Palliation of painful bone metastases from prostate cancer using sodium etidronate: results of a randomized, prospective, double-blind, placebo-controlled study.

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J Urol. 1989 Jan;141(1):85-7.
Palliation of painful bone metastases from prostate cancer using sodium etidronate: results of a randomized, prospective, double-blind, placebo-controlled study.
Smith JA Jr.
SourceDepartment of Surgery, University of Utah Health Sciences Center, Salt Lake City 84132.
AbstractSodium etidronate is a diphosphonate compound that inhibits bone resorption and mineralization. The drug has been reported to be highly effective for the palliation of painful bone metastasis from prostatic cancer. Fifty-seven patients were entered into a randomized, prospective, double-blind, placebo-controlled study of sodium etidronate. All patients had hormone refractory metastatic prostatic cancer and bone pain requiring analgesics. No difference was seen in the symptomatic response rate or analgesic requirement between patients treated with sodium etidronate and placebo. With the dose scheme used in this study sodium etidronate was ineffective for palliation of bone pain from prostatic cancer.
PMID: 2462069 [PubMed - indexed for MEDLINE]

[Shahid]

Prostate cancer being one of the most dangerous health risks this randomized study is a welcome effort to highlight the effectiveness sodium nitrate.